Apologies for my delay in posting a new blog but I have been completing my book "Introduction to Horse Nutrition" which has taken ages (60,000 words!) and the deadline was looming.
I thought I would mention for horses with Insulin Resistance, Cushings or Equine Metabolic Syndrome there is some new information in humans suggesting that glucosamine may cause an increase in Insulin Resistance by causing a traffic jam in one of the paths that glucose takes when it's being used in cells. This was when glucosamine was injected but there hasn't been much human evidence on oral glucosamine and Insulin Resistance.
It is possible that the horse has a different mechanism. Studies involving participants with already high blood sugar states showed negative effects of glucosamine on IR, while normal blood sugar participants showed no effects on insulin resistance . Since most horses do not appear to suffer from high blood sugar, glucosamine may not have this negative effect on IR. Glucosamine has been used orally for many years without insulin resistance being reported as a side effect and has been considered safe.
So, at present, it would seem wise to simply keep an eye on the horse and only stop glucosamine if there are any adverse effects or if there is no improvement in the movement/arthritis.
If any further information comes to light I will let you know
Zoe

